Anti Neuronal Cell Antibody

General Information

Lab Name

Anti Neuronal Cell Ab

Lab Code

ANEUR

Epic Name

Anti Neuronal Cell Antibody

Description

Elevated serum or CSF anti-neuronal cell antibody levels may help in the diagnosis of neuropsychiatric systemic lupus erythematosus (SLE). This test should not be mistaken for the assay for anti-neuronal nuclear antibodies (ANNA), which include anti-Hu, Yo, and Ri antibodies. These other tests may be ordered to evaluate some forms of paraneoplastic peripheral neuropathies associated with various malignancies, and are not currently performed at the University of Washington (they are send-out tests).

    ***Order Alert: Effective 11/20/2025, serum and cerebrospinal anti-neuronal cell antibody testing is temporarily unavailable due to an assay reagent issue. The duration of the downtime is unknown, but clients will be informed once testing resumes. Please contact Client Support Services at 206-520-4600 for any questions.***

    References

    1. Ho RC, et al. A meta-analysis of serum and cerebrospinal fluid autoantibodies in neuropsychiatric systemic lupus erythematosus. Autoimmun Rev 2016, 15:124-38. 26497108
    2. West SG, Emlen W, Wener MH, and Kotzin BL. Neuropsychiatric lupus erythematosus: a 10-year prospective study on the value of diagnostic tests. Am J Med 1995, 99:153-63. 7625420

    Components

    Code Name
    ANEU Anti Neuronal Cell Ab
    IINTP1 Interpretation
    ANMTH Anti Neuronal Cell Ab Method

    Interpretation

    Method

    ELISA using stable, isolated neuronal membrane extracts.

    Reference Range

    See individual components

    Ref. Range Notes

    Established by testing healthy blood donor samples during method validation in 1987. Confirmed in 2005, 2010, 2012, 2015, and 2018.

    Guidelines

    Ordering & Collection

    Specimen Type

    Blood

    Collection

    3 mL blood in RED TOP or SST tube

    Quantity

    requested: 1 mL serum
    minimum: 0.5 mL serum

    Processing

    Freeze serum at -20°C

    Stability: Freezer: Long Term; Refrig: 14 d

    Performance

    LIS Dept Code

    Immunology (IMM)

    Performing Location(s)

    UW-MT Immunology
    206-520-4600

    Clinical Lab, Room NW220,
    University of Washington Medical Center,
    1959 NE Pacific street, Seattle, WA 98195

    Frequency

    Monday, Wednesday

    Available STAT?

    No

    Billing & Coding

    CPT codes

    83520

    LOINC

    32853-4

    Interfaced Order Code

    UOW156